Fmoc-2-(piperidine-3-yl)acetic acid
Fmoc-2-(piperidine-3-yl)acetic acid
CAS: 885951-96-2
Molecular Formula: C22H23NO4
Fmoc-2-(piperidine-3-yl)acetic acid - Names and Identifiers
Fmoc-2-(piperidine-3-yl)acetic acid - Physico-chemical Properties
| Molecular Formula | C22H23NO4 |
| Molar Mass | 365.42 |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD02181112 |
Fmoc-2-(piperidine-3-yl)acetic acid - Risk and Safety
| Hazard Class | IRRITANT |
Fmoc-2-(piperidine-3-yl)acetic acid - Introduction
Fmoc-2-(piperidin-3-yl) acetic acid is an organic compound with the chemical formula C24H23NO4. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
Fmoc-2-(Piperidin-3-yl) acetic acid is a white to pale yellow solid. It is stable at room temperature and soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane (DCM) and acetonitrile. It is a derivative of Fmoc protecting group and is an important reagent commonly used in organic synthesis.
Use:
Fmoc-2-(piperidin-3-yl) acetic acid is commonly used as a protecting group for peptide synthesis, particularly in solid phase synthesis. By introducing Fmoc-2-(piperidin-3-yl) acetic acid into the amino terminal of the peptide chain, it is possible to prevent non-specific oxidation, acidolysis, or enzymatic hydrolysis during the reaction.
Preparation Method:
The preparation method of Fmoc-2-(piperidin-3-yl) acetic acid is relatively complicated, and is generally completed by a two-step reaction. First, 2-piperidinoacetic acid and trichloromethane sulfonate are reacted to produce 2-(piperidin-3-yl) acetic acid trichloromethane sulfonate. This product is then reacted with Fmoc-OH to give the final Fmoc-2-(piperidin-3-yl) acetic acid.
Safety Information:
Fmoc-2-(Piperidin-3-yl) acetic acid is a chemical and should be used under suitable laboratory conditions. It may be irritating to the skin, eyes and mucous membranes, so the body and eyes should be protected and direct contact should be avoided during the operation. At the same time, the handling and storage specifications of the relevant chemicals should be observed to avoid contact with incompatible substances. The safe handling of the compound should be determined according to the specific experimental conditions and the use environment.
Nature:
Fmoc-2-(Piperidin-3-yl) acetic acid is a white to pale yellow solid. It is stable at room temperature and soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane (DCM) and acetonitrile. It is a derivative of Fmoc protecting group and is an important reagent commonly used in organic synthesis.
Use:
Fmoc-2-(piperidin-3-yl) acetic acid is commonly used as a protecting group for peptide synthesis, particularly in solid phase synthesis. By introducing Fmoc-2-(piperidin-3-yl) acetic acid into the amino terminal of the peptide chain, it is possible to prevent non-specific oxidation, acidolysis, or enzymatic hydrolysis during the reaction.
Preparation Method:
The preparation method of Fmoc-2-(piperidin-3-yl) acetic acid is relatively complicated, and is generally completed by a two-step reaction. First, 2-piperidinoacetic acid and trichloromethane sulfonate are reacted to produce 2-(piperidin-3-yl) acetic acid trichloromethane sulfonate. This product is then reacted with Fmoc-OH to give the final Fmoc-2-(piperidin-3-yl) acetic acid.
Safety Information:
Fmoc-2-(Piperidin-3-yl) acetic acid is a chemical and should be used under suitable laboratory conditions. It may be irritating to the skin, eyes and mucous membranes, so the body and eyes should be protected and direct contact should be avoided during the operation. At the same time, the handling and storage specifications of the relevant chemicals should be observed to avoid contact with incompatible substances. The safe handling of the compound should be determined according to the specific experimental conditions and the use environment.
Last Update：2024-04-10 22:29:15
